Methylene Blue
Methylene blue is a synthetic dye, that was originally used to color paper, wool, silk, and cotton fabric. Later it was used by researchers as a stain for identifying bacteria and parasites.arasites.
In medicine – it is an antioxidant that can help a rare blood disorder that affects how red blood cells work in the body.
It has previously been used for treating cyanide poisoning and urinary tract infections, but this use is no longer recommended.
Methylene blue is a medication and laboratory-made dye that has been repurposed for many different uses. However, it’s only approved to treat acquired methemoglobinemia. People who are pregnant or nursing, take medications that raise serotonin levels, or have a G6PD deficiency should avoid this medication.
It does not really have a ‘feel’ impact or energizing effect. It is not without risk. Methylene blue has a boxed warning — the FDA’s most serious type of warning — for a risk of serotonin syndrome when used with other medications that raise serotonin levels. Serotonin syndrome is a potentially life-threatening condition that is caused by too much serotonin in the brain. Symptoms can include muscle spasms, sweating, and agitation, among others.
https://www.goodrx.com/methylene-blue/methylene-blue-uses
https://my.clevelandclinic.org/health/diseases/24115-methemoglobinemia
The dietary supplement “Recharge” by TWC (The Wellness Company) is $98.99 a month on smartship.
They have 2 ingredients – Urolithin A, and Methylene Blue.
They claim it increases ATP (energy in the cell) and promotes healthy aging, healthy brain, and is an antioxidant.
1. 500 mg Methylene Blue – not approved as a dietary supplement. May have serious side effects at 500mg, their dosage.
“Generally considered unsafe at this high dose without medical supervision: While lower doses of methylene blue (e.g., 10-30mg) may be explored for off-label uses, 500 mg is significantly above the typical range and poses potential risks.
Potential for Serotonin Syndrome: Combining 500 mg of methylene blue with serotonergic drugs (like many antidepressants) dramatically increases the risk of serotonin syndrome, a potentially life-threatening condition.
Other Risks: Even without drug interactions, high oral doses can cause gastrointestinal issues, methemoglobinemia (iron in the blood unable to carry oxygen) at doses exceeding 7 mg/kg, and other adverse effects.”
Some medicines that should not be taken with methylene blue include:
“Certain medicines for depression or anxiety, including bupropion (Aplenzin, Forfivo, Wellbutrin), clomipramine (Anafranil), citalopram (Celexa), doxepin (Silenor), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), trazodone, and venlafaxine (Effexor)
Monoamine oxidase inhibitors (MAOIs) for depression, such as isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine (Parnate)
Milnacipran (Savella), which treats fibromyalgia
Mirtazapine (Remeron), a tetracyclic antidepressant
Rasagiline (Azilect) and selegiline (Eldepryl, Emsam, Zelapar), Parkinson’s disease treatments
St. John's wort, a supplement
Tryptophan, a supplement
Antidepressant medications are a concern because of a complication called serotonin syndrome. Serotonin syndrome is a drug reaction that happens when medication combinations create high levels of serotonin in your body. You can have mild symptoms like shivering and diarrhea or severe symptoms like muscle rigidity, fever, and seizures. It can even cause death if you don't treat it.”
https://www.webmd.com/a-to-z-guides/methylene-blue
2. Urolithin – A – 30mg – found in food like pomegranate, berries, walnuts – may support muscle health and fight inflammation. Need to be careful if have liver or kidney issues. It is an antioxidant and promotes healthy aging.
Research has been primarily in rodent models, and more human research is needed. Generally considered safe.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10609777/
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